Chromosomal Segregation Defects in Cancer Cells: Formation of Anaphase Bridges and Multipolar Spindles

Genomic instability is a common phenomenon in cancer. The vast majority of cancers frequently exhibit gross structural, chromosomal alterations such as translocations, deletions, and amplifications. These chromosomal alterations may arise from errors during cell division or repair of DNA damage. Of these errors, segregational defects such as anaphase bridges and multipolar spindles play a major role in chromosomal instability, leading to tumorigenesis. However, little is known about the mechanistic details on how these form. By reading this book, you will gain insights into the background, terminology and underlying reasons causing these anomalies. While the main emphasis is on how DNA repair proteins potentially lead to anaphase bridges, the effects of ionizing radiation on multipolar spindle formation is also discussed. Readers working in cancer field, especially those interested in errors in cell division will greatly benefit from this book. Moreover, the book should also please instructors teaching cell biology with the quality of images showing various defects of cells in mitosis.