Multitarget Opioid Ligands As Suitable Candidates for Pain Management: Pharmacolgical Fingerprint of the Benzomorphan-based Opioid Compound Lp1 - Lorella Pasquinucci - Bøger - LAP LAMBERT Academic Publishing - 9783659562266 - 2. juli 2014
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Multitarget Opioid Ligands As Suitable Candidates for Pain Management: Pharmacolgical Fingerprint of the Benzomorphan-based Opioid Compound Lp1

Lorella Pasquinucci

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Multitarget Opioid Ligands As Suitable Candidates for Pain Management: Pharmacolgical Fingerprint of the Benzomorphan-based Opioid Compound Lp1

For the clinical management of acute and chronic pain, a possible therapeutic approach is the association between two or more drugs, which produce their biological effects on two or more different sites of action, in order to modulate directly or indirectly profile analgesic and adverse effects. Given the advantages of polypharmacology, in the drug discovery process has been established the strategy "one-molecule multiple targets". Considering that the various mediators involved in the circuit of pain represent potential targets for different pharmacological interventions, opioid-opioid or non-opioid-opioid multitarget ligands are potential drug candidates for the management of pain conditions. Multitarget ligands, able to act simultaneously on multiple opioid receptors subtypes, showed low propensity to induce side effects. Three chapters constitute this contribution; the first is focused on pain mechanisms and mediators and examine the main drugs clinically used. The second chapter list known multitarget opioid ligands. Finally, the third chapter deal with the LP1 pharmacological fingerprint, a suitable drug candidate for acute and chronic pain management.

Medie Bøger     Paperback Bog   (Bog med blødt omslag og limet ryg)
Udgivet 2. juli 2014
ISBN13 9783659562266
Forlag LAP LAMBERT Academic Publishing
Antal sider 72
Mål 152 × 229 × 4 mm   ·   117 g
Sprog Engelsk