Dissolution for Sodium Alginate Floating Pellets of Metronidazole: Evalution & in Vitro Release Kinetics

Metroinidazole floating pellet were prepared by extrusions, spheronization, method and drug release profile of metronidazole were investigated. Different batches of pellets were prepared by using sodium alginate and HPMCK4M and HPMC K100LV as polymer. In vitro dissolution of pellets was carried out in USP apparatus XXIV (Paddle Method) 50rpm. The drug release was measured by using UV spectroscopy at 277nm for acid buffer media. The dissolution data were treated with Zero Order, First Order and Higuchi Model. Half of the formulations were fitted to Higuchi Model and to the First Order Model. Finally it can be concluded that, with the increasing of polymer concentration to an optimum level, the release rate (23.18%) of metronidazole was satisfactory but further increase causes decrease of metronidazole release.