Data Analysis for Mass Spectrometry-based Proteomics: Novel Data Analysis Methods and Algorithms for Identification of Peptides and Proteins by Use of Tandem Mass Spectrometry - Hua Xu - Bøger - VDM Verlag Dr. Müller - 9783639105254 - 18. december 2008
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Data Analysis for Mass Spectrometry-based Proteomics: Novel Data Analysis Methods and Algorithms for Identification of Peptides and Proteins by Use of Tandem Mass Spectrometry

Hua Xu

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Data Analysis for Mass Spectrometry-based Proteomics: Novel Data Analysis Methods and Algorithms for Identification of Peptides and Proteins by Use of Tandem Mass Spectrometry

Tandem mass spectrometry is one of the most important tools for protein analysis. This work is focused on the development of new methods and algorithms for tandem mass spectrometry data analysis. A database search engine, MassMatrix, has also been developed that incorporates these methods and algorithms. The program is publicly available both on the web server at www.massmatrix.net and as a deliverable software package for personal computers. Three different scoring algorithms have been developed to identify and characterize proteins and peptides by use of tandem mass spectrometry data. In addition, a data analysis method for identification of disulfide bonds in proteins and peptides by tandem mass spectrometry data has been developed and incorporated in MassMatrix. By this new approach, proteins and peptides with disulfide bonds can be directly identified in tandem mass spectrometry with high confidence without any chemical reduction and/or other derivatization.

Medie Bøger     Paperback Bog   (Bog med blødt omslag og limet ryg)
Udgivet 18. december 2008
ISBN13 9783639105254
Forlag VDM Verlag Dr. Müller
Antal sider 236
Mål 322 g
Sprog Engelsk  

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